Abbreviation: 46LA1 Load: 45(L) + 15(S) + 0(CP) + 0(EXE) + 0(P) + 0(ST) + 0(LE) + 0(ME) + 0(SCP) + 0(FE) + 0(CE) + 0(PP) + 0(MSCP)
Lecturers in charge: dr. sc. Lana Feher Turković
Course description: Prevoditelj
Isključi neposredan prijevod
Lectures: Basics of biochemistry, role and historical overview of developments in biochemistry. Metabolism (anabolism, catabolism). Build stations; organelles, composition and construction of biological membranes, membrane receptors, the passage of substances through the cell membrane, active transport. Proteins - the three-dimensional structure of proteins, the role of dietary protein, essential amino acids, resorption and transport of amino acids. Rearrangement of amino acids. Digestion of proteins. Urea cycle. Biosynthesis of nonessential amino acids. Enzymes - Classification and chemical nature of enzymes. The mechanisms of enzymatic catalysis. Inhibition of enzyme activity. Hemoglobin - hemoglobin as an allosteric protein, sickle-cell anemia, hemoglobin biosynthesis and degradation. Myoglobin as a carrier of oxygen. Carbohydrates - monosaccharides, oligosaccharides, polysaccharides, digestion of carbohydrates, glucose catabolism (glycolysis), glycogen biosynthesis (gluconeogenesis), degradation of glycogen (glycogenolysis), anaerobic way of creating lactate and alanine Cori cycle, gluconeogenesis, pentose phosphate cycle. Control of blood sugar levels. Metabolism of fructose and galactose. Lipids - compound fats, phospholipids, sterols, fatty acids, lipids significant energy, degradation of triglycerides in the intestinal tract, lipase, bile acid, the catabolism of triglycerides and fatty acids, biosynthesis of fatty acids, biosynthesis of glycerophospholipids. Lipoproteins. Energy aspects of metabolism - respiratory chain and oxidative phosphorylation, biological redox systems. Citric acid cycle, acetyl-SCoA catabolism. Nucleotide metabolism - the structure and function of nucleic acids, genetic role, structure and replication, DNA damage, genetic code and protein synthesis, inhibitors of protein synthesis, regulation of gene expression, recombination, biosynthesis and catabolism of purines and pyrimidines,
Seminars: Experimental Methods in biochemical research. Coenzyme - prosthetic groups and cosubstrate; their role in enzyme catalysis and specificity of interaction with the substrate. Coenzyme as hydrogen carriers and transmitters of the group. Micronutrients. The metabolism of cholesterol. The hormones of the endocrine glands, hormones tissue, structure and function of hormones, features hormonal system, mechanisms of action of hormones, hormone regulation. Gastrointestinal hormones. Porphyrins and porphyria. Metabolism of water and electrolytes. The association citrate cycle with other metabolic processes. The metabolism of xenobiotics. Connection of metabolism of carbohydrates, lipids and proteins. The metabolism of adipose, muscle, and liver. Free radicals and oxidative stress
Lecture languages: - - -
Compulsory literature:
1. Berg, J. M., Tymoczko, J. L., Stryer, L. Biokemija, Školska knjiga, Zagreb, 2013. (odabrana poglavlja)
Recommended literature:
2. Murray, R. K., Bender, D. A., Kennelly, P. J., Rodwell, V. W., Weil, P. A.; Harperova ilustrirana biokemija, prijevod 28. izdanja, Medicinska naklada Zagreb, 2011
3. Čvoriščec, D., Čepelak, I. (ur.) Štrausova medicinska biokemija, Medicinska naklada, Zagreb, 2009.
L - Lectures
FE - Field exercises
CE - Project laboratory
PP - Preclinical practicals
MSCP - Mentorship of special clinical practicals
S - Seminar
CP - Clinical practicals
EXE - Exercises of applied kinesiology
P - Practicum
ST - Sectio training
LE - Laboratory exercises
ME - Methodology exercises
SCP - Special clinical practicals
* - Not graded